Publications


45. Fluorinated Water-Soluble Poly(2-oxazoline)s as Highly Sensitive 19F MRI Contrast Agents

Sedlacek, O.,* Jirak, D., Vit, M., Ziołkowska, N., Janouskova, O., and Hoogenboom, R.* Macromolecules 2020, DOI: 10.1021/acs.macromol.0c01228


Pre – Charles University publications

2020

44. Drug Delivery Systems Based on Poly(2‐Oxazoline)s and Poly (2‐Oxazine)s
Sedlacek, O.,* and Hoogenboom, R.* Adv. Ther. 2020, 3, 1900168

43. Poly (2-methyl-2-oxazoline) conjugates with doxorubicin: From synthesis of high drug loading water-soluble constructs to in vitro anti-cancer properties
Sedlacek, O.,* Van Driessche, A., Uvyn, A., De Geest, B., and Hoogenboom, R.* J. Control. Release 2020, 326, 53

42. Reactive oxygen species (ROS)-responsive polymersomes with site-specific chemotherapeutic delivery into tumors via spacer design chemistry
Jager, E., Sincari, V., Albuquerque, L., Jager, A., Humajova, J., Kucka, J., Pankrac, J., Paral, P., Heizer, T., Janouskova, O., Konefał, R., Pavlova, E., Sedlacek, O., Giacomelli, F.C., Pouckova, P., Sefc, L., Stepanek, P., and Hruby, M. Biomacromolecules 2020, 21 (4) 1437

41. Poly(2-ethyl-2-oxazoline) Conjugates with Salicylic Acid via Degradable Modular Ester Linkages
Bernhard, Y., Sedlacek, O., Van Guyse, J., Bender, J., Zhong, Z., De Geest, B. G., and Hoogenboom, R. Biomacromolecules 2020, DOI: 10.1021/acs.biomac.0c00659

40. Implant-forming polymeric 19F MRI-tracer with tunable dissolution
Kolouchova, K., Jirak, D., Groborz, O., Sedlacek, O., Ziolkowska, N., Vit, M., Sticova, E., Galisova, A., Svec, P., Trousil, J., Hajek, M., and Hruby, M., J. Control. Release 2020, DOI: 10.1016/j.jconrel.2020.07.026


2019

39. Unexpected Reactivity Switch in the Statistical Copolymerization of 2-Oxazolines and 2-Oxazines Enabling the One-Step Synthesis of Amphiphilic Gradient Copolymers
Sedlacek, O., Lava, K., Verbraeken, B., Kasmi, S, De Geest, B., Hoogenboom, R. J. Am. Chem. Soc., 2019, 141, 24, 9617-9622

38. Straightforward route to new poly (2-oxazoline)s via acylation of well-defined polyethyleneimine
Sedlacek, O., Janouskova, O., Verbraeken, B., Hoogenboom, R. Biomacromolecules, 2019, 20, 1, 222-230

37. Poly (2-amino-2-oxazoline)s: a new class of thermoresponsive polymers
Sedlacek, O.*, Bera, D., Hoogenboom. R.* Polym. Chem., 2019, 10, 34, 4683-4689.

36. Visualization and design of the functional group distribution during statistical copolymerization
Van Steenberge, P., Sedlacek, O., Hernandez-Ortiz, J., Verbraeken, B., Reyniers, M.-F., Hoogenboom, R., D’hooge, D. Nat. Commun., 2019, 10, 1, 1-14.

35. Solvent-control over monomer distribution in the copolymerization of 2-oxazolines and the effect of a gradient structure on self-assembly
Bera, D., Sedlacek, O., Hoogenboom, R. Polym. Chem., 2019, 10, 37, 5116-5123

34. Poly(2-oxazoline)-protein conjugates
Sedlacek, O., Rosa., V., Hoogenboom, R. Eur. Polym. J., 2019, 120, 109246.

33. Synthesis of defined high molar mass poly(2-methyl-2-oxazoline)
Sedlacek, O.*, Monnery, B., Hogenboom, R.* Polym. Chem., 2019, 10, 11, 1276-1290

32. Poly(2-oxazoline)s One-Pot Polymerization and Surface Coating: From Synthesis to Antifouling Properties Out-Performing Poly(ethylene oxide)
Svoboda, J., Sedlacek, O., Riedel, T., Hruby, M., Pop-Georgievski, O. Biomacromolecules, 2019, 20, 9, 3453-3463.

31. SET‐LRP Synthesis of Well‐Defined Light‐Responsible Block Copolymer Micelles
Sedlacek, O.*, Filippov, S., Svec, P., Hruby, M. Macromol. Chem. Phys., 2019, 220, 19, 1900238


2018

30. Defined High Molar Mass Poly(2‐Oxazoline)s
Monnery, B., Jerca, V., Sedlacek, O., Verbraeken, B., Cavill, R., Hoogenboom, R. Angew. Chem. Int. Ed., 2018, 57, 47, 15400-15404

29. 19F Magnetic Resonance Imaging of Injectable Polymeric Implants with Multiresponsive Behavior
Sedlacek, O.*, Jirak, D.,* Galisova, A., Jager, E., Laaser, J., Lodge, T., Stepanek, P., Hruby, M.* Chem. Mater., 2018, 30, 15, 4892-4896

28. Self-Assembled Thermoresponsive Polymeric Nanogels for 19F MR Imaging
Kolouchova, K., Sedlacek, O., Jirak, D., Babuka, D., Blahut, J., Kotek, J., Vit, M., Trousil, J., Konefal, R., Janouskova, O., Podhorska, B., Slouf, M., Hruby., M. Biomacromolecules, 2018, 19, 8, 3515-3524

27. Biopolymer strategy for the treatment of Wilson’s disease
Vetrik, M., Mattova, J., Mackova, H., Kucka, J., Pouckova, P., Kukackova, O., Brus, J., Eigner-Henke, S., Sedlacek, O., Sefc, L., Stepanek, P., Hruby, M. J. Control. Release, 2018, 273, 131-138

26. Polymer nitric oxide donors potentiate the treatment of experimental solid tumours by increasing drug accumulation in the tumour tissue
Studenovsky, M., Sivak, L., Sedlacek, O., Konefal, R., Horkova, V., Etrych, T., Kovar, M., Rihova, B., Sirova, M. J. Control. Release, 2018, 269, 214-224

25. Porous heat-treated polyacrylonitrile scaffolds for bone tissue engineering
Vetrik, M., Parizek, M., Hadraba, D., Kukackova, O., Brus, J., Hlidkova, H., Komankova, L., Hodan, J., Sedlacek, O., Slouf, M., Bacakova, L., Hruby, M., ACS Appl. Mater. Interfaces, 2018, 10, 10, 8496-8506

24. Conformational properties of biocompatible poly (2-ethyl-2-oxazoline) s in phosphate buffered saline
Gubarev, A., Monnery, B., Lezov, A., Sedlacek, O., Tsvetkov, N., Hoogenboom, R., Filippov, S. Polym. Chem., 2018, 9, 17., 2232-2237


2017

23. Poly(2-ethyl-2-oxazoline) conjugates with doxorubicin for cancer therapy: in vitro and in vivo evaluation and direct comparison to poly [N-(2-hydroxypropyl) methacrylamide] analogues
Sedlacek, O.*, Monnery, B., Mattova, J., Kucka, J., Panek, J., Janouskova, O., Hocherl, A., Verbraeken, B., Vergaelen, M., Zadinova, M., Hoogenboom, R.,* Hruby, M.* Biomaterials, 2017, 146, 1-12

22. A simple neridronate-based surface coating strategy for upconversion nanoparticles: highly colloidally stable 125I-radiolabeled NaYF4: Yb3+/Er3+@ PEG nanoparticles for multimodal in vivo tissue imaging
Kostiv, U., Lobaz, V., Kucka, J., Svec, P., Sedlacek, O., Hruby, M., Janouskova, O., Francova, P., Kolarova, V., Sefc, L., Horak, D. Nanoscale, 2017, 9, 43, 16680-16688

21. Therapeutic targeting of non-coding RNAs in cancer
Slaby, O., Laga, R., Sedlacek, O. Biochem. J., 2017, 474, 24, 4219-4251

20. Reductively Degradable Poly (2-hydroxyethyl methacrylate) Hydrogels with Oriented Porosity for Tissue Engineering Applications
Mackova, H., Plichta, Z., Hlidkova, H., Sedlacek, O., Konefal, R., Sadakbayeva, Z., Duskova-Smrckova, M., Horak, D., Kubinova, S. ACS Appl. Mater. Interfaces, 2017, 9, 10544-10553

19. Radiolabelled Polymeric Materials for Imaging and Treatment of Cancer: Quo Vadis?
Pant, K., Sedlacek, O., Nadar, R., Hruby, M., Holger, S. Adv. Healthcare Mater., 2017, 6, 6, 1601115

18. The effect of ionizing radiation on biocompatible polymers: From sterilization to radiolysis and hydrogel formation
Sedlacek, O.*, Kucka, J., Monnery, B.D., Slouf, M., Vetrik, M., Hoogenboom, R., Hruby, M. Polym. Degrad. Stab., 2017, 137, 1-10


2016

17. Thermoresponsive polymers for nuclear medicine: Which polymer is the best?
Sedlacek, O., Cernoch, P., Kucka, J., Konefal, R., Stepanek, P., Vetrik, M., Lodge, T.P., Hruby, M. Langmuir, 2016,  32, 6115-6122

16. Double stimuli-responsive polymer systems: How to use crosstalk between pH-and thermosensitivity for drug depots
Bogomolova, A., Kaberov, L., Sedlacek, O., Filippov, S.K., Kral, V., Wang, X.Y., Liu, S.L., Ye, X.D., Hruby, M. Eur. Polym. J., 2016, 84, 54-64


2015

15. Optimized protocol for the radioiodination of hydrazone-type polymer drug delivery systems
Sedlacek, O., Kucka, J., Hruby, M. Appl. Radiat. Isot., 2015, 95, 129-134

14. Multi Responsive Polymer Micelles as Ellipticine Delivery Carriers for Cancer Therapy
Studenovsky, M., Sedlacek, O., Hruby, M., Panek, J., Ulbrich, K. Anticancer Res., 2015, 35 (2), 753-757


2014

13. Multistage-targeted pH-responsive polymer conjugate of Auger electron emitter: optimized design and in vivo activity
Sedláček, O., Studenovský, M., Větvička, D., Ulbrich, K., Hrubý, M. Bioorg. Med. Chem. 2013, 21 (18), 5669-5672

12. Glycogen-graft-poly(2-alkyl-2-oxazolines) – the new versatile biopolymer-based thermoresponsive macromolecular toolbox
Pospisilova A., Filippov, S.K, Bogomolova, A., Turner, S., Sedlacek, O., Matushkin, N., Cernochova, Z., Stepanek, P., Hruby, M. RSC Adv., 2014,4, 61580-61588

11. Silver-coated monolithic columns for scavenging of radioactive iodine
Sedlacek, O., Kucka, J., Svec, F., Hruby, M. J. Sep. Sci. 2014, 7 (37), 798-802

10. Study of Complex Thermosensitive Amphiphilic Polyoxazolines and Their Interaction with Ionic Surfactants. Are Hydrophobic, Thermosensitive and Hydrophilic Moieties Equally Important?
Bogomolova, A., Filippov, S., Starovoytova, L., Angelov, B., Konarev, P., Sedlacek, O., Hruby, M., Stepanek, P. J. Phys. Chem. B2014, 118 (18), 4940–4950


2013

9. Fine tuning of the pH-dependent drug release rate from polyHPMA-ellipticinium conjugates
Sedláček, O., Studenovský, M., Větvička, D., Ulbrich, K., Hrubý, M. Bioorg. Med. Chem. 2013, 21 (18), 5669-5672

8. SAXS and light scattering study of hybrid nanoparticles composed of thermoresponsive triblock copolymer F127 and thermoresponsive statistical poly-oxazolines with hydrophobic moieties
Bogomolova, A., Hruby, M., Panek, J., Rabyk, M., Turner, S., Bals, S., Steinhart, M., Zhigunov, A., Sedlacek, O., Stepanek, P., Filippov, S. J. Appl. Crystallogr. 2013, 46 (6), 1690-1698

7. Chelating polymeric particles intended for the therapy of Wilson’s disease
Škodová, M., Kučka, J., Vetrík, M., Skopal, J., Walterová, Z., Sedláček, O., Štěpánek, P., Mattová, J., Poučková, P., Urbánek, P., Hrubý, M. React. Funct. Polym. 2013, 73 (11), 1426-1431

6. Collective polyelectrolyte diffusion as a function of counterion size and dielectric constant
Filippov, S., Seery, T.,A., P., Kříž, J., Hrubý, M., Černoch, P., Sedláček, O., Kadlec, P., Pánek, J., Štěpánek, P. Polym. Int. 2013, 62 (9), 1271-1276


2012

5. Glycogen as Biodegradable Construction Nanomaterial for in vivo Use
Filippov, S., Sedlacek, O., Bogomolova, A., Vetrik, M., Jirak, D., Kovar, J., Kucka, J., Bals, S., Turner, S., Stepanek, P., Hruby, M. Macromol. Biosci. 2012, 12 (12), 1731-1738

4. Poly(2-oxazoline)s – where are they more advantageous for biomedical applications than other polymer types? 
Sedláček, O.,Monnery B., D.,Filippov, S.,Hoogenboom, R.,Hrubý, M.  Macromol. Rapid Commun. 2012, 33 (19), 1648-1662

3. Polymer conjugates of acridine-type anticancer drugs with pH-controlled activation
Sedláček, O., Hrubý, M., Studenovský, M., Větvička, D., Svoboda, J., Kaňková, D., Kovář, J., Ulbrich, K. Bioorg. Med. Chem. 2012, 20 (13), 4056-4063


2011

2. Ellipticine-aimed polymer-conjugated Auger electron emitter: multistage organelle targeting approach
Sedláček O., Hrubý M., Studenovský M., Kučka J., Větvicka D., Kovář L., Ulbrich K. Bioconjug. Chem. 2011, 22(6), 1194-1201

1. The synthesis of the 8-C-substituted 2,6-diamino-9-[2-(phosphonomethoxy)ethyl]purine (PMEDAP) derivatives by diverse cross-coupling reactions
Sedláček, O., Břehová, P., Pohl, R., Holý, A., Janeba, Z. Can. J. Chem. 2011, 89, 488-498